A 42-year-old woman with newly diagnosed rheumatoid arthritis is started on methotrexate. Two months later, she reports fatigue and oral ulcers. Labs: Hb 9.8 g/dL, WBC 2,400/µL, ALT 65 IU/L. Which of the following agents can reverse these adverse effects?, A. Folic acid, B. Vitamin B12, C. Leucovorin*, D. Prednisolone, A 45-year man presents to your office with symptoms of depression and also reports a desire to quit smoking. You mention starting a trial of antidepressants but the gentleman opposes because of well-known sexual side effects. Which antidepressant would you try first on him due to its low risk of causing sexual dysfunction and its success as a smoking-cessation aid?, A. Bupropion*, B. Milnacipran, 45-year-old woman with a history of anxiety and chronic pain is scheduled for a minimally invasive endoscopic procedure to investigate gastrointestinal symptoms. The anesthesiologist decides to induce conscious sedation with a drug combination that has the advantage of being reversible by the administration of specific receptor antagonists. Which of the following pairs of drugs was most likely administered ?, A. Fentanyl and thiopental, B. Fentanyl and midazolam*, C. Fentanyl and ketamine, D. Thiopental and midazolam, E. Thiopental and ketamine

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