Heritability, Can be calculated using the concordance between monozygotic and dizygotic twins, Recurrence risk ratio, Can be calculated using prevalence of disease in family members and the general population, Dizygotic twins, Share 50% of their DNA and 100% of their initial environment, Monozygotic twins, Share 100% of their DNA and 100% of their initial environment, Germline variants, Occur in every cell of the body, Somatic variants, Absent in gamete, can occur at any time during development or after birth

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