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At rest, the actin and myosin are not connected., Troponin and tropomyosin are blocking the binding sites for myosin., The nerve impulse reaches the neuromuscular junction. , Calcium causes synaptic vesicles to release Acetylcholine (neurotransmitter) into the synapse., Acetylcholine travels across the synapse and opens the sodium channels on the other side, allowing the electrical impulse to continue., The sarcoplasmic reticulum releases calcium., The calcium binds to troponin and tropomyosin., Troponin and tropomyosin move, exposing the binding sites on actin., Using ATP, the myosin heads bind to the actin-myosin binding site and perform the power stroke, moving the proteins closer together., This causes a muscle contraction..

Neuromuscular junction


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