Osmotic Diuretics: Easily filtered but not eeasily reabsorped, Increases osmolarity of nephron tubular fluid by increasing number of electrolytes, Same MOA that causes diabetics to have increased urinary output, Doesn't decrease BP or Blood Volume, Reduces fluid in tissues/organs, Used in cerebral oedema, Used in glaucoma, Dehydration and headaches, Loop Diuretics: Act in ascending loop of henley, Inhibit Na+/Cl-/K+ cotransporter (Nephron-> Blood), Prevents ≈25% Na+ reabsorption, Most Effective Diuretic, Hypocalcemia, Ototoxic, Treat hyperkalemia or hypercalcemia, Thiazides: Act at distal convoluted tubule, Better for preventing kidney stones, Hypercalcemia, Erectile Dysfunction, Disruption of muscle-contractile activity, More effective hypertension treatment, Prevents ≈5-10% of Na+ reabsorption, Treats hyperkalemia but not hypercalcemia, Mineralocorticoid antagonist potassium sparing diuretics: Spironolactone is an example, Used to treat aldosterone induced hypertension, Gynaecomastia, Sexual dysfunction (In all sexes), Both thiazides and loop diuretics: Hypomagnesia, Hypokalemia, Alkalosis, Treat Hypertension, Reduce blood volume, Used to treat heart failure, Dehydration, Treat overdose (By increasing speed of elimination), Ion-Channel Blocking Potassium-Sparing diuretics: Block non-gated sodium channel, Prevents the need for Na+/K+ ATPase transport, Reduces the amount of K+ moved from blood-nephron, All potassium-sparing diuretics: Rarely used alone, Don't cause hypokalemia, Can cause hyperkalemia, Prevent <5% Na+ reabsorption,

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