CYP2D6: Involved in ≈25% of drug metabolisis pathways, Only makes up 3% of CYPs in liver, Bimodal distribution (Rate of metabolism), The minority are intermediate or poor metabolisers, Sparteine and Debrisoquine can be used as probe drugs, Ultrarapid metabolisers have 2-13 functional gene copies, CYP3A5: 25 Allelic variants, African Americans and south-east Asians tend to be high metabolisers, High metabolisers require higher doses of tacrolimus (Immunosuppressant), The minority of the world (esp. white) are high metabolisers, Both: Interethnic differences, Native americans, Pacific Islanders and Oceanic Nations have high proportions of high metabolisers, High metabolisers are less likely to experience dose-limiting toxicities, Low metabolisers are more likely to experience SEs,

Cytochrome p450 Enzyme Polymorphisms Sort

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