1) What is reperfusion injury in the context of angina? a) The damage that occurs when blood flow is restricted to the heart muscle during angina. b) The injury that results from the sudden restoration of blood flow to the heart after a period of reduced blood supply. c) The inflammation of the coronary arteries in angina patients. d) The scarring of the heart muscle caused by chronic angina. 2) What specific cellular mechanism does trimetazidine primarily target to mitigate reperfusion injury? a) It activates protein kinase C to reduce oxidative stress. b) It enhances the release of endothelin-1 to improve coronary vasoconstriction. c) It upregulates pro-inflammatory cytokines to stimulate tissue regeneration. d) It inhibits the opening of mitochondrial permeability transition pores, potentially reducing cell death. 3) What is the specific numerical threshold typically used to define an abnormal FFR measurement, indicating a hemodynamically significant coronary artery stenosis? a) 0.60 b) 0.50 c) 0.80 d) 1.0 4) Which is true about Fractional Flow Reserve? a) Measures the arterial pressure by comparing the close and open vessels b) The amount of blood flow through a coronary artery during exercise. c) Measure the arterial pressure by comparing the distal and proximal pressure  d) Left ventricular ejection fraction 5) What was the effect of adding Trimetazidine (TMZ) to standard normal saline hydration in high-risk patients with renal insufficiency undergoing angioplasty or angiography? a) It had no impact on the incidence of CIN. b) It reduced the incidence of CIN by 2-fold. c) It reduced the incidence of CIN by 3-fold. d) Trimetazidine is given after patient develops CIN 6) Which is true about global longitudnal strain? a) To analyse the change of regional myocardial segments b) Detects late changes in myocardial function c) Severe impairment of longitudnal myocardial deformation is 0.9/s d) Measured by 3D Echo 7) Which is true about cardiac enzymes? a) Troponins elevate within 6 to 12 hours in patients with acute MI b) CK- MB stays for days in blood c) CK-MB elevates within 6 to 12 hours d) Troponins normalises after 48-72 hrs duringr MI 8) Fraction flow Reserve is discussed in: a) PATMOS study b) Zhang et al study c) Chen et al d) Wang et al 9) Harjoko et al studied the following: a) Decrease in value of GLS strain b) Increase GLS values in patients with HFpEF c) Trimetazidine 20mg for 12 weeks d) Significant IHD from previous coronary angiogram, h/o ACS, H/o Revascularisation 10) Improvement in exercise capacity was assessed in: a) Kim et al b) Michaelidis et al. c) Leonova et al d) Ivan Ilic 11) Kim et al studied that improvement in MACE frees survival rate in CCS patients with Diabetes was: a) 86% b) 76% c) 96% d) 66% 12) Wang et al study on meta-analysis studied the following: a) Incidence of Ischemic changes reduced to 84% b) Incidence of Ischemic changes reduced to 31% c) Incidence of Ischemic changes reduced to 71% d) Incidence of Ischemic changes reduced to 24% 13) Incidence of angina attacks reduced at what percentage in wang etal meta-analysis a) 21% b) 84% c) 31% d) 76% 14) PREAMI is the second study with an ACE inhibitor after AIRE to be done in patients with acute MI with preserved ejection fraction a) True b) False 15) In Europa substudy, Perindopril reduced the recurrence of MI by a) 26% b) 27% c) 29% d) 25% 16) In Europa substudy (Bertrand et al), following number of patients were studied a) 7910 b) 12218 c) 1252 d) 6723 17) Safety of Perindopril see in EUROPA when compared to HOPE and SOLVD: a) 1.2% b) 2.4% c) 1.4% d) 2.2% 18) What was the patient group studied in EUROPA study a) History of MI and No revascularisation b) H/O MI and/ or H/O Revascularisation c) H/O Revascualrisation and No MI d) H/O MI and H/O revascularisation 19) In EUROPA study, HF hospitalization reduced to  a) 36% b) 40% c) 39% d) 37% 20) The following is true about PREAMI study a) Perindopril 8mg was used in elderly patients having acute MI with reduced ejection fraction b) Perindopril 8mg was used in elderly patients having acute MI with preserved ejection fraction c) Perindopril 8mg significantly reduced LV remodelling by 56% vs placebo d) Perindopril 8mg significantly reduced hospitalisation for heart failure by 39%

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