1) What is the primary application of complexation in the pharmaceutical industry? a) Decreasing drug solubility b) Improving drug stability c) Enhancing drug bioavailability d) Reducing drug efficacy 2) Which method is commonly used to analyze complexation reactions quantitatively? a) Spectrophotometry b) Chromatography c) Mass spectrometry d) X-ray crystallography 3) In the context of protein binding, what does the term "bioavailability" refer to? a) The concentration of drug in the bloodstream b) The fraction of the drug that reaches systemic circulation c) The rate of drug metabolism d) The elimination half-life of the drug 4) What is the term used to describe the three-dimensional arrangement of atoms in a complex? a) Crystal arrangement b) Crystal lattice c) Coordination sphere d) Crystallography 5) Which crystalline structure of complexes involves the host molecule trapping the guest molecule within its structure? a) Inclusion complex b) Coordination complex c) Molecular complex d) Metal-ligand complex 6) What is the thermodynamic treatment used to quantify the stability of a complex? a) Enthalpy change b) Gibbs free energy change c) Entropy change d) Internal energy change 7) In complexation, what is the term used to describe the ratio of the concentration of the complex to the concentrations of the free ligands? a) Stability constant b) Binding constant c) Formation constant d) Dissociation constant 8) Which method is commonly used to determine protein binding of drugs in biological fluids? a) Chromatography b) Spectrophotometry c) Nuclear magnetic resonance (NMR) d) Radioimmunoassay (RIA) 9) What is the primary factor influencing drug-protein binding in the bloodstream? a) Drug solubility b) Drug lipophilicity c) Drug charge d) Drug size 10) In protein binding, what term is used to describe the reversible association of a drug with proteins in the bloodstream? a) Covalent binding b) Non-specific binding c) Specific binding d) Allosteric binding

Quiz 4 (Unit 4)

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