White blood cells (such as macrophages) detect pathogens and release cytokines., Step1, Cytokines signal the hypothalamus to raise the body’s temperature set point., Step 2, The hypothalamus increases the set point, and the body responds by shivering and generating heat — the temperature rises, Step 3, Immune cells become more active, attacking pathogens more efficiently as the fever continues., Step 4, When the infection is controlled, the set point returns to normal, causing sweating and cooling of the body., Step 5.

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