1) What is the primary characteristic of osteosarcoma? a) Formation of mature cartilage b) Direct formation of osteoid or bone matrix by tumor cells c) Presence of multinucleated giant cells d) Absence of new bone formation 2) Which genetic mutation is commonly associated with osteosarcoma? a) TP53 and retinoblastoma gene mutations b) BRCA1 c) PTEN gene deletion d) APC gene mutation 3) What is the most common site for primary osteosarcoma? a) Skull bones b) Vertebrae c) Metaphysis of long bones, especially around the knee d) Phalanges 4) What is a characteristic radiological feature of osteosarcoma? a) Onion skin appearance b) Codman’s triangle and sunburst appearance c) Ground-glass opacity d) Soap-bubble appearance 5) What is the most common route of metastasis in osteosarcoma? a) Lymphatic spread b) Direct invasion into the peritoneum c) Hematogenous spread to the lungs d) Neural spread

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