Nitric Oxide (iNO) - Increases pulmonary blood flow through the relaxation of smooth muscle. Inhaled., Epoprostenol (Veletri) - Decreases pulmonary vascular resistance, mean pulmonary artery pressure, and mean systemic arterial pressure. Inhaled or IV, Sildenafil - Produces smooth muscle relaxation. PO or IV, Treprostnil (Remodulin) - Vasodilator of the pulmonary and systemic vascular beds. Given SubQ, Epinephrine - Causes vasoconstriction, increases systemic & pulmonary resistance, increases BP and improves oxygenation., Dexmedetomidine (Precedex) - Sedative. Administer via continuous IV drip. Can cause significant bradycardia and arrhythmias., Phenylephrine - Stimulates receptors on the blood vessels, leading to vasoconstriction. Increases BP and HR without affecting the rhythm, Morphine - Used for pain and/or sedation. Begin with PRN dose. Can decrease BP, Vasopressin - Acts on smooth muscle to induce vasoconstriction, increasing BP. Can significantly increase MAPs, HR and systemic vascular resistance, Hydrocortisone - Higher doses increase systolic and diastolic BP, Bosentan - Decreases pulmonary artery pressure, pulmonary vascular resistance, and mean atrial pressure. You must wear gloves and a mask when handling.,

Medications to Treat Pulmonary Hypertension-NICU Addition

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