Properties - Bind to Ag-Ab complex; Binds to Fc portion of Ab; Species non-specific; Heat labile, Pathways of innate immunity - Lectin pathway and alternate pathway, Pathway of acquired immunity - Classical pathway, Initiators of pathways - Classical- Binding of C1 complex with Ag-Ab complex; Lectin- Binding of MBL directly on microbes; Alternate-Spontaneous hydrolysis of C3, C3 convertase - Classical & Lectin pathway-C4b2a; Alternate-C3bBb , C5 convertase - Classical & Lectin pathway-C4b2a3b;Alternate-C3bBb3b, Functions - Opsonisation for phagocytosis; Immune complex clearance; Chemotaxis and inflammation; Cell lysis, Anaphylotoxins, Opsonins, MAC - C3a & C5a- Anaphylotoxins; C3b & C4b- Opsonins; C5b to C9- MAC.,
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Immunology- Complement system
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