Dierct: cortical projections excite the striatum (direct), striatum inhibits GPI, GPI inhibition releases thalamic neurons from inhibition, allowing them to fire, MOVEMENT, Indirect: cortical projections excite the striatum (indirect), striatum inhibits GPE, decrease in activity of GPE results i less inhibition of the subthalamic nucleus, subthalamic nuclei are disinhibited and excite GPI, GPI make increased inhibitory connections with the thalamus, thalamus cannot excite the cortex, NO MOVEMENT,

Direct vs. indirect pathways

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