Stimulus is applied (NT binding to receptor acts as ligand), Positive ions enter through ligand-gated ion channels, Threshold value is reached, triggers opening of v-gated sodium channels, Positive sodium ions rush into the cell, V-gated sodium channels close and v-gated potassium channels open, Positive potassium ions flow out through v-gated potassium channels, Brief period where excess positive ions have left the cell, Resting membrane potential maintained by sodium-potassium pump.

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