1) Glucocorticoids, prednisone, etc a) Inhibits phospholipase A2 b) Schizophrenia c) Inhibits cyclooxygenase 1 & 2 [COX-1 & 2] d) Anti-inflammatory, immunosuppressant e) LTC, D, E receptor antagonist f) Asthma 2) NSAIDS a) Inhibits phospholipase A2 b) Schizophrenia c) Inhibits cyclooxygenase 1 & 2 [COX-1 & 2] d) Anti-inflammatory e) LTC, D, E receptor antagonist f) Asthma 3) Zileuton a) Inhibits lipoxygenase [LOX] b) Schizophrenia c) Inhibits cyclooxygenase 1 & 2 [COX-1 & 2] d) Anti-inflammatory e) LTC, D, E receptor antagonist f) Asthma 4) Montelukast, Zafirlukast a) Inhibits lipoxygenase [LOX] b) Schizophrenia c) Inhibits cyclooxygenase 1 & 2 [COX-1 & 2] d) Anti-inflammatory e) LTC, D, E receptor antagonist f) Asthma 5) Diphenhydramine a) Histamine [H1] blockade b) Schizophrenia c) 5-HT2 antagonist d) Allergies e) LTC, D, E receptor antagonist f) Asthma 6) Clozapine a) Histamine [H1] blockade b) Schizophrenia c) 5-HT2 antagonist d) Allergies e) LTC, D, E receptor antagonist f) Asthma 7) Leukotrienes a) used in the treatment of migraine headaches, carcinoid syndrome, nausea, vomiting, schizophrenia b) produced primarily in inflammatory cells, including mast cells, basophils, eosinophils, macrophages, & polymorphonuclear leukocytes c) LTB4 d) primary mediator of allergic reactions e) LTA4, LTC4, LTD4 receptor f) derived from arachidonic acid 8) Serotonin (5-HT) a) used in the treatment of migraine headaches, carcinoid syndrome, nausea, vomiting, schizophrenia b) vasodilation in vascular smooth muscle c) vasoconstriction in vascular smooth muscle d) contraction of GI and other non-vascular smooth muscle e) contraction of bronchial and other non-vascular smooth muscle f) stimulation of platelet aggregation 9) Histamine a) used in the treatment of migraine headaches, carcinoid syndrome, nausea, vomiting, schizophrenia b) vasodilation in vascular smooth muscle c) inhibition of gastric acid secretion d) contraction of GI and other non-vascular smooth muscle e) contraction of bronchial and other non-vascular smooth muscle f) stimulation of platelet aggregation 10) Prostaglandin E (PGE) a) decreased bronchial tone b) vasodilation in vascular smooth muscle c) inhibition of gastric acid secretion d) relaxation of bronchial muscle, contraction of uterine muscle e) contraction of bronchial muscle, relaxation of uterine muscle f) stimulation of platelet aggregation 11) Prostaglandin E (PGE) a) decreased bronchial tone b) vasodilation in vascular smooth muscle c) inhibition of gastric acid secretion d) relaxation of bronchial muscle, contraction of uterine muscle e) contraction of bronchial muscle, relaxation of uterine muscle f) stimulation of platelet aggregation

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