1) 3yo boy is seen in emergency dept. He is lethargic and has decreased urine output for the past day. He had bloody diarrhea last week which resolved. PE: afebrile, periorbital edema, cutaneous petechiae. Labs: decreased platelet count. Urine analysis: 3+ blood, 2+ protein. Cause of condition? a) IgG against platelet receptor b) Large vWF multimers c) Shiga toxin d) Splenic sequestration 2) 3yo boy is seen in emergency dept. He is lethargic and has decreased urine output for the past day. He had bloody diarrhea last week which resolved. PE: afebrile, periorbital edema, cutaneous petechiae. Labs: decreased platelet count. Urine analysis: 3+ blood, 2+ protein. What would be seen on peripheral blood smear? a) Bite cells b) Echinocytes c) Howell-Jolly bodies d) Schistocytes 3) A 36-year-old female has Gram-negative sepsis after a urinary tract infection. PE: fever, petechiae on her extremities, and bleeding in the mouth, IV site, and urine. Which of the following would be seen on lab test?.  a) High platelet count, Normal bleeding time, PT, PTT b) Low platelet count, Increased bleeding time, PT, PTT c) Low platelet count, Normal bleeding time, High PT, PTT d) Normal platelet count, bleeding time, High PT, PTT 4) A 36-year-old female has Gram-negative sepsis after a urinary tract infection. PE: fever, petechiae on her extremities, and bleeding in the mouth, IV site, and urine. Diagnosis? a) Disseminated intravascular coagulation b) Hemolytic-Uremic syndrome c) Immune thrombocytopenic purpura d) Thrombotic thrombocytopenic purpura 5) A 20-year-old female is seen in the emergency dept. She i. s lethargic, disoriented, and confused. PE: fever, pallor, petechial rash on trunk. Labs: elevated BUN, creatinine, decreased platelets. Peripheral blood smear shows fragmented red cells. Diagnoisis? a) Disseminated intravascular coagulation b) Hemolytic-Uremic syndrome c) Immune thrombocytopenic purpura d) Thrombotic thrombocytopenic purpura

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