Phosphorylated tau protein - ID protein accumulation type, ApoE4 - Which ApoE isoform increases amyloid deposits?, ApoE2 - Which ApoE isoform decreases amyloid deposits?, Cerebral amyloid angiopathy - A 45yo patient with Down syndrome presents with signs of stroke. CTscan shows lobar intracerebral hemorrhage. Cause?, Beta-pleated sheet formation - Autopsy on a 82yo female with 15yr history of dementia shows vesselswalls with protein deposits. Congo Red stain reviewed under polarized light identifies presence of amyloid. What is it's tertiary structure? , APP, Presenilin-1, & presenilin-2 - Familial forms of Alzheimer disease is associated with which gene mutations?, Early personality & behaviorl changes, aphasia - Clinical feature of frontotemporal dementia, Presence of Pick bodies or TDP-43 - Histology of frontotemporal dementia, Tau protein - Composition of Pick bodies, APP gene located on chromosome 21. Trisomy 21 has increased APP production - Why would Down syndrome have increased risk for Alzheimer disease?, Nucleus basalis of Meynert has Acetylcholine production. This area has decreased ACh in Alzheimer disease - Why would researchers look into nucleus basalis of Meynert in Alzheimer disease?, Amyloid-beta protein - APP cleavage by beta-amyloid converting enzyme produces what protein?, Chronic traumatic encephalopathy - A 50yo retired football player has increasing memory loss, behavior change and mood disturbances. Diagnosis?, Neurofibrillary tangles - A 52yo retired professional football player has increasing memory loss, behavior change and mood disturbances. What would be seen histologically in brain?,

Alzheimer disease: Pathology

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