1) In a DNA strand the nucleotides are linked together by: a) glycosidic bonds b) phosphodiester bonds c) peptide bonds d) hydrogen bonds 2) A nucleoside differs from a nucleotide. It lacks the: a) base b) sugar c) phosphate group d) hydroxyl group 3) Both deoxyribose and ribose belong to a class of sugars called: a) trioses b) hexoses c) pentoses d) polysaccharides 4) The fact that a purine base always paired through hydrogen bonds with a pyrimidine base leads to, in the DNA double helix: a) the antiparallel nature b) the semiconservative nature c) uniform width throughout DNA d) uniform length in all DNA 5) Which of the following are the functions of RNA? a) t is a carrier of genetic information from DNA to ribosomes synthesising polypeptides. b) It carries amino acids to ribosomes. c) It is a constituent component of ribosomes. d) All of the above. 6) Which was the last human chromosome to be completely sequenced: a) Chromosome 1 b) Chromosome 11 c) Chromosome 21 d) Chromosome X 7) Regulatory proteins are the accessory proteins that interact with RNA polymerase and affect its role in transcription. Which of the following statements is correct about regulatory protein? a) They only increase expression b) They only decrease expression c) They interact with RNA polymerase but do not affect the expression d) They can act both as activators and as repressors 8) Discontinuous synthesis of DNA occurs in one strand, because: a) DNA molecule being synthesised is very long b) DNA dependent DNA polymearse catalyses polymerisation only in one direction (5’ →3’) c) it is a more efficient process d) DNA ligase has to have a role 9) DNA is a polymer of nucleotides which are linked to each other by 3’-5’ phosphodiester bond. To prevent polymerisation of nucleotides, which of the following modifications would you choose? a) Replace purine with pyrimidines b) Remove/Replace 3′ OH group in deoxy ribose c) Remove/Replace 2′ OH group with some other group in deoxy ribose d) Both ‘B’ and ‘C’ 10) Who amongst the following scientists had no contribution in the development of the double helix model for the structure of DNA? a) Rosalind Franklin b) Maurice Wilkins c) Erwin Chargaff d) Meselson and Stahl 11) The human chromosome with the highest and least number of genes in them are respectively: a) Chromosome 21and Y b) Chromosome 1 and X c) Chromosome 1 and Y d) Chromosome X and Y 12) The promoter site and the terminator site for transcription are located at: a) 3′ (downstream) end and 5′ (upstream) end, respectively of the transcription unit b) 5′ (upstream) end and 3′ (downstream) end, respectively of the transcription unit c) the 5′ (upstream) end d) the 3′ (downstream) end

MCQ Molecular Basis of Inheritance

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