CISPLATIN - Alkylating Agent that is causes Nephrotoxicity. Corticosteroid & Serotonin Antagonist Antiemetics are recommended with the use of this medication. Often prescribed with Trastuzumab, Fluorouracil, or Capecitabine. Most widely used platinum compound in pancreatic cancer., CYCLOPHOSPHAMIDE - Alkylating Agent that causes Cystitis. A nitrogen mustard derivative. Better absorbed then others and can be administered PO. Monitor creatinine clearance., OXALIPLATIN - Alkylating Agent that can cause numbness/tingling and pain in the throat and hands. Swallowing and ADLs that require hand grasping may be impaired. Patients should be taught to avoid exposure to cold weather, cold fluids, during therapy and for 3-5 months after administration, FLUORURACIL - Antimetabolite that can cause cold sensitivity/paresthesia of the hands and feet. Can cause hand-foot syndrome. Often prescribed with Trastuzumab, Cisplatin, or Capecitabine. Orally administered and used as a radiosensitizer during radiation. Was approved along with Leucovorin to be used in metastatic pancreatic adenocarcinoma. Can also be given with Leucovorin, and Oxaliplatin for colon cancer. Patients should increase their intake of fluids with this medication., CAPECITABINE - Antimetabolite that causes Hand-Foot Syndrome. Considered a radiosensitizer during radiation therapy. Can be given IV or PO. Often prescribed with Trastuzumab, Fluorouracil, and Cisplatin. Also used in a new combination drug therapy with Oxaliplatin for 3-6 months. Associated with improved survival/less recurrence in colon cancer., METHOTREXATE - Antimetabolite that can cause Nephrotoxicity, and Hepatotoxicity. Can be given intrathecally. Monitor creatinine clearance, ALT, AST. Teach to avoid alcohol, aspirin, and prolonged exposure to sunlight., GEMCITABINE - Is the standard of care for patients with metastatic pancreatic cancer, and has been found to length survival. Can cause mild proteinuria and hematuria during clinical trials, and hemolytic-uremic syndrome (anemia, elevated bilirubin and reticulocyte counts, and renal failure) if this occurs the med must be stopped immediately and hemodialysis may be required., BLEOMYCIN - Anti-tumor agent that can cause pulmonary fibrosis. This medication has a cumulative max dose that can be given for cancer treatment without a risk of irreversible vital organ damage. Has a rare possibility of nephrotoxicity. Its elimination half-life is prolonged with CrCl is less than 35 mL/min. Often used in pancreatic and colon cancer., DAUNORUBICIN - Anti-tumor agent that can cause cardiotoxicity, Hepatotoxicity. Formulations require reduction according to serum bilirubin levels., DOCETAXEL - Miotic Spindle Inhibitor that can cause severe peripheral neuropathy, called the dying-back process. Affects the distal nerve and Schwann cells, and neuronal cells. Hematopoietic Growth Factors (Granulocyte Colony-Stimulating Factors) should be initiated in severe neuropathy or a neutrophil count less than 500 for 1 week or longer., LEUCOVORIN - Is a medication given to protect normal cells from destruction and prevent toxicity of antineoplastic medications. Its action is similar to that of folic acid, TRASTUZUMAB - A recombinant humanized anti-HER-2. It is a targeted antineoplastic agent that binds to the growth factor receptors found on blood vessels, colorectal cancer cells, breast cancer cells, to prevent intracellular growth factors from becoming activated and stimulating cell growth. Often used with Fluorouracil, Cisplatin, Capecitabine in patients with gastric cancer that are HER-2 Positive. Can cause cardiotoxicity (dyspnea, edema, HF),

SPECIFIC CANCER MEDS

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