Arrival of an action potential at axon terminal (synaptic knob) of presynaptic neuron, depolarizes the presynaptic membraneIf the depolarization is above threshold level, an action potential is produced at postsynaptic membrane and is transmitted along the postsynaptic neuron. , Generate excitatory postsynaptic potential (EPSP), Na+ diffuse into the postsynaptic neurons and leads to depolarization of the postsynaptic membrane., The binding of neurotransmitter to the receptors causes ligand-gated ion channels to open., The neurotransmitter diffuses across the synaptic cleft and bind to a specific receptor on the ligand-gated ion channel on the postsynaptic membrane., Synaptic vesicle releases the neurotransmitter into the synaptic cleft by exocytosis., Diffusion of Ca2+ trigger synaptic vesicles to fuse with the presynaptic membrane., Ca²+ from extracellular fluid diffuse into synaptic know., The following step is? - Opening of voltage-gated calcium(Ca²+) channels, presynaptic neuron membrane becomes more permeable to Ca²+., The first step of transmission of impulsive is? - Arrival of an action potential at axon terminal (synaptic knob) of presynaptic neuron, depolarizes the presynaptic membrane ,

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