osmoreceptors in hypothalamus detect decrease in H2O potential of blood when water moves out of osmoreceptor cells down H2O potential gradient, causing cells to shrink, electrical impulses sent along sensory neurone to the posterior pituitary gland, PPG releases ADH (made in hypothalamus) into the blood, ADH binds to cells of collecting duct, increasing H2O permeability of the cells by stimulating the insertion of aquaporins into the plasma membrane of the cells of the CD wall, water molecules move by osmosis from high H2O potential in the collecting duct lumen, to a lower water potential in the collecting duct wall cells (across a PPM, through an aquaporin) and then into the medulla tissue fluid and the blood, a smaller volume of more concentrated urine is produced.

Osmoregulation

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