Which of the following would NOT cause a pathologic fracture, Lytic bone metastasis, Osteogenesis imperfecta, Osteomyelitis, Osteoporosis, Paget disease of bone, Trauma, A 62yo wman has wrist pain after falling down in the grocery parking lot. Radiograph shows a Colles fracture. DEXA scan with T-score -3.2. VitD, calcium, phosphorus and PTH levels are normal. What mechanism contributes to the bone pathology?, Defective collagen type 1 production, Defect in osteoid mineralization, Lack of sun exposure, RANK-L elevation, 18 yoM has worsening right thigh pain for the past 2-3 months. There is tenderness to palpation above the right knee. A radiograph shows a bony sunburst pattern, cortical bone fracture, and elevated periosteum. What most likely caused this pathologic fracture?, Genetic , Immune-mediated, Infectious, Metabolic, Neoplastic, Traumatic, A 63yoM presents with severe back pain. Radiograph shows a pathologic fracture with lytic lesions. Labs show normal calcium and PTH levels. Biopsy confirms metastatic carcinoma. Which mediator is responsible for osteoclastic activation?, Fibroblast growth factor (FGF), Matric metalloprotease (MMP), PTH-related protein (PTHrp), Reeptor activator of Nuclear Factor -kappa B ligand (RANKL), A 56yo F has metastatic breast cancer. Which of following treatment is used for preventing pathologic fractures?, Bisphosphonate therapy, Calcium supplements, Exercise and weight-bearing, Radiation therapy to affected bone.

Pathologic fractures

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