What are they?, Assists the body's immune system during cancer, Interferons, Colony-stimulating factors, Interleukins, Destroy of interfere with tumor activities (cytotoxic/cytostatic effects), Interleukins, A group of signaling proteins produced by leukocytes (T lymphocytes), Increase growth and activity of other T & B cells, Interferons, Alpha, beta, gamma, Interferon Alfa 2B: antiviral drug that treats hepatitis and cancer, binding to human type 1 interferon receptors and dimerizing (bind to similar receptor) and signal to the nucleus, Route: IV, IM, SubQ, SE: chest pain, confusion, blurred vision, injection site reaction, Monitor for injections, autoimmune disorders, mental illness., Monitor for depression or behavioral changes, Colony-stimulating factors, Regulate growth, maturation, and differentiation of bone marrow stem cells, Permit the delivery of higher doses of drugs and reduce bone marrow recovery time after bone marrow transplantation, Enhance macrophage or granulocyte tumor, viruses, and fungi., Prevents severe thrombocytopenia, Epoetin alfa & Filgrastim, Epoetin Alfa (procrit, epogen) Erythropoietin, signaling the bone marrow to make more red blood cells, use to treat anemia of chronic renal failure, cancer chemotherapy, SE/AR: HTN, arthralgia, edema, fatigue, N/V/D, CHEST PAIN, seizures, THROMBOSIS, Special considerations: monitor hemaglobin!!!, DO NOT ADMINISTER WITH HEMOGLOBIN 11 g/dL OR GREATER, Filgrastim (neupogen)- Granulocyte, stimulates production, maturation and activation of neutrophils within the bone marrow, use: prevention of neutropenia and associated infection in patients who hace received bone marrow depressing antineoplastics, DO NOT GIVE 24 hrs before or 24 hrs after chemotherapy !!!, Monitor neutrophil count to assess effectiveness., Sudden LUQ pain and fullness in a patient on filgrastim raises concern for splenic enlargement or rupture (rare, but serious).

Biologic Response Modifiers (BRM)

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