1) A 19-year-old male military recruit is deployed to Africa and given anti-malarial prophylaxis. After 3 days, he complains of fatigue, dizziness, and blood in the urine. Labs: normocytic anemia, high retic count, LDH, AST. Cause? a) G6PD-deficiency b) IgG-mediated hemolysis c) Lack of decay accelerating factor d) PK deficiency 2) A 19-year-old male military recruit is deployed to Africa and is given anti-malarial prophylaxis. After 3 days, he complains of fatigue, dizziness, and blood in the urine. Labs: normocytic anemia, high retic count, LDH, AST. Management? a) Discontinue medication use; avoid oxidant stressor b) Obtain blood and send for flow cytometry c) Provide iron supplements d) Recommend genetic workup since autosomal recessive inheritance pattern 3) A 19-year-old male military recruit is deployed to Africa and is given anti-malarial prophylaxis. After 3 days, he complains of fatigue, dizziness, and blood in the urine. Labs: normocytic anemia, high retic count, LDH, AST. Blood smear would show: a) Basophilic stippling b) Heinz bodies c) Howell-Jolly bodies d) Schistocytes 4) Define Heinz body a) Denatured hemoglobin b) DNA inclusions c) Iron within mitochondria d) Ribosomal RNA aggregates 5) A 19-year-old female has a history of normocytic anemia, jaundice and mild splenomegaly. Peripheral blood smear shows presence of echinocytes. Diagnosis? a) G6PD deficiencye b) Lead poisoning c) PK deficiency d) Sickle cell anemia 6) A 19-year-old female has a history of normocytic anemia, jaundice and mild splenomegaly. Peripheral blood smear shows presence of echinocytes. She is deficient in which rate-limiting step of what metabolic pathway? a) Cori cycle b) Embden-Meyerhof pathway c) Glycogenolysis d) Hexose monophosphate pathway 7) A 19-year-old female has a history of normocytic anemia, jaundice and mild splenomegaly. Peripheral blood smear shows presence of echinocytes. What else would be identified? a) Bite cells b) Hemoglobinuria c) Increased 2,3- BPG d) Increased ATP
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Red cell enzyme deficiencies
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