to set off appositives, to link two independent clauses., to take the place of omitted letters from contractions., to set off the name of the person addressed (spoken to), to separate items in complex sentences, to highlight the first letter in speech., after greetings in a business letters, to form compound words, between words or groups of words in a series., in the openings of friendly letters and in the closings of all letters., to separate items in dates and places., to set off words that interrupt the main idea of a sentence., to separate adjectives before a noun., in quotations., before a coordinate conjunction in a compound sentence., to set off introductory words and phrases., to set off non-essential words and phrases.

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