All of the following are characteristics of the ideal local anesthetic except, a. sterilization by autoclave., b. slow onset., c. reversible., d. absence of local reactions., Which portion of the chemical structure of a typical local anesthetic is considered lipophilic (lipid soluble)?, a. Aromatic nucleus, b. Amino group, c. Both A and B, d. Neither A nor B, The mechanism of local anesthetics involves action on, a. myelinated nerve., b. axons., c. sodium channels., d. Both A and C., e. Both B and C., Repolarization of a nerve occurs by, a. influx of potassium., b. influx of sodium., c. efflux of potassium., d. efflux of calcium., e. None of the above, The following states are characteristics of the salt form of a local anesthetic except which one?, a. Charged, cation (ionized), b. Alkaline, c. Crystalline solid, d. Stable, In the presence of an acidic environment, such as infection or inflammation, the amount of free base is reduced; therefore _____ of the local anesthetic is in the ionized form, making anesthesia _____ difficult., a. more; more, b. more; less, c. less; more, d. less; less, The cationic form of a local anesthetic is needed to penetrate the nerve membrane, and the free base form exerts blocking action by binding to the specific receptor site., a. Both statements are true., b. Both statements are false., c. The statement is true, the second is false., d. The first statement is false, the second is true., Reducing the rate of systemic absorption of a local anesthetic is important when it is used in dentistry because, a. otherwise, too large an area would be anesthetized., b. if not, the anesthesia would not last long enough to complete a dental procedure., c. the chance of systemic toxicity is reduced., d. local anesthesia is associated with respiratory depression., Addition of vasoconstrictor to local anesthetic (1) reduces blood supply to the area, (2) increases blood supply to the area, (3) limits systemic absorption, (4) increases systemic absorption, (5) reduces systemic toxicity, and (6) increases systemic toxicity. Which of these are correct?, a. 1, 3, 5, b. 1, 4, 5, c. 2, 3, 5, d. 2, 3, 6, e. 2, 4, 6, Local anesthetics cross, a. the placenta and blood-brain barrier., b. the placenta but not the blood-brain barrier., c. the blood-brain barrier but not the placenta., d. neither the placenta nor the blood-brain barrier., Amide local anesthetics are metabolized, a. by being hydrolyzed by plasma pseudocholinesterases., b. primarily by the liver., c. in the spleen., d. minimally and are excreted virtually unchanged, Procaine (Novocaine) is metabolized primarily by the, a. liver., b. lungs., c. plasma., d. kidneys., Which of the following local anesthetic agents have the potential to cause methemoglobinemia as an adverse effect?, a. Prilocaine and lidocaine, b. Lidocaine and mepivacaine, c. Prilocaine and mepivacaine, d. Prilocaine and articaine, e. Mepivacaine and articaine, Which nerve function is the most sensitive to inhibition by local anesthetic agents?, a. Touch, b. Warmth, c. Pressure, d. Autonomic, e. Pain, The maximum safe dose of articaine 4% with 1:100,000 epinephrine is approximately _____ cartridges., a. 5.5, b. 6.9, c. 8.5, d. 11.5, Which of the following agents are the most likely to precipitate malignant hyperthermia: (1) halothane, (2) lidocaine, (3) mepivacaine, (4) succinylcholine?, a. 1, 2, 3, 4, b. 2, 3, 4, c. 2, 3, d. 1,4, Which of the following local anesthetics is safest to use for dental treatment for a pregnant women? , a. Mepivacaine, b. Lidocaine, c. Articaine, d. Bupivacaine, Which of the following components of an injected amide local anesthetic agent may produce a hypersensitivity reaction that exhibits itself as an acute asthmatic attack?, a. The vasoconstrictor, b. The antioxidant for the vasoconstrictor, c. The sodium hydroxide, d. The sodium chloride, Epinephrine is combined with local anesthetics so as to, a. enhance absorption., b. prolong duration of action., c. delay onset., d. increase potency., The correct ADA color code for articaine 4% with epinephrine 1:100,000 is, a. black., b. green., c. red., d. gold., e. brown., Lidocaine with epinephrine 1:100,000 provides a _____ duration of pulpal anesthesia., a. 30-minute, b. 30- to 60-minute, c. 60- to 90-minute, d. 90-minute or more, Which of the following statements is true of mepivacaine?, a. Cross-allergenicity has been demonstrated between mepivacaine and other currently available amides., b. Mepivacaine is effective topically., c. Mepivacaine can be used as a 3% solution without a vasoconstrictor., d. The benefit of a shorter duration of anesthesia warrants eliminating the vasoconstrictor., Levonordefrin is commonly combined with which local anesthetic?, a. Lidocaine, b. Procaine, c. Mepivacaine, d. Bupivacaine, Several cases of methemoglobinemia have been reported after the use of, a. lidocaine., b. mepivacaine., c. prilocaine., d. articaine., Prilocaine plain has a duration of action slightly _____ than mepivacaine plain, and prilocaine with epinephrine has a duration of action slightly _____ than lidocaine with epinephrine., a. shorter; shorter, b. shorter; longer, c. longer; shorter, d. longer; longer, Which of the following local anesthetics has the longest duration of action?, a. Lidocaine, b. Mepivacaine, c. Prilocaine, d. Bupivacaine, Which local anesthetic agent is derived from thiophene?, a. Tetracaine, b. Bupivacaine, c. Articaine, d. Propoxycaine, Which of the following local anesthetic agents is both an ester and an amide?, a. Benzonatate, b. Articaine, c. Bupivacaine, d. Dyclonine, Approximately _____% of articaine is metabolized by the liver., a. 5 to 10, b. 20 to 25, c. 50 to 75, d. 90, Which of the following dental local anesthetics is associated with an increased incidence of paresthesia following an inferior alveolar (IA) block?, a. Lidocaine 2% with epinephrine 1:100,000, b. Lidocaine 2% with epinephrine 1:50,000, c. Mepivacaine 2% with levonordefrin 1:20,000, d. Prilocaine 4% with epinephrine 1:200,000, e. Articaine 4% with epinephrine 1:100,000, _____ is an ester local anesthetic, a. Prilocaine (Citanest), b. Tetracaine (Pontocaine), c. Bupivacaine (Marcaine), d. Lidocaine (Xylocaine), Which local anesthetic agent is neither an ester nor an amide?, a. Propoxycaine, b. Dyclonine, c. Articaine, d. Lidocaine, Which of the following dental local anesthetic agents is available in a 1.7 ml dental cartridge unlike the more common 1.8 ml dental cartridge?, a. Lidocaine (Xylocaine, Octocaine), b. Bupivacaine (Marcaine), c. Mepivacaine (Carbocaine, Isocaine), d. Prilocaine (Citanest), e. Articaine (Septocaine), The vasoconstrictors are members of the autonomic nervous system drugs called the, a. adrenergic agonists., b. adrenergic antagonists., c. cholinergic agonists., d. cholinergic antagonists., Plain anesthetics without vasoconstrictor will exhibit a _____ duration of action and result in a _____ rapid buildup of a systemic blood level, a. shorter; less, b. shorter; more, c. longer; less, d. longer; more, Patients with uncontrolled high blood pressure, hyperthyroidism, angina pectoris, and cardiac arrhythmias and those who have had a myocardial infarction or cerebrovascular accident in the past _____ should make an appointment for elective dental treatment only after their medical condition is under control., a. 6 weeks, b. 3 months, c. 6 months, d. 12 months, The maximum safe dose of epinephrine for the cardiac patient is _____ mg., a. 0.02, b. 0.04, c. 0.2, d. 0.4, Which is the concentration of levonordefrin (Neo-Cobefrin) used in dentistry?, a. 1:20,000, b. 1:50,000, c. 1:100,000, d. 1:200,000, A cardiac patient can be given _____ cartridges of a dental anesthetic with epinephrine 1:100,000 without exceeding the cardiac dose for the vasoconstrictor., a. 0.5, b. 2, c. 4, d. 6, Which two agents are known to cause clinically significant drug interactions when combined with epinephrine?, a. Selective serotonin reuptake inhibitors and nonselective -blockers, b. Nonselective -blockers and phenothiazines, c. Tricyclic antidepressants and monoamine oxidase inhibitors, d. Nonselective -blockers antagonists and tricyclic antidepressants, e. Benzodiazepines and monoamine oxidase inhibitors, Which of the following agents is the most common topical local anesthetic?, a. Lidocaine, b. Benzocaine, c. Tetracaine, d. Dyclonine, Which of the following local anesthetics may be combined for injection-free local anesthesia?, a. Articaine and bupivacaine, b. Lidocaine and prilocaine, c. Benzocaine and tetracaine, d. Lidocaine and articaine, Each of the following will decrease the ability of dental local anesthetic to penetrate the nerve fiber except one. Which is the exception?, a. Local inflammation, b. Dilution by fluid, c. Infection, d. Free-base form, Which dental local anesthetic is an ester?, a. Lidocaine, b. Mepivacaine, c. Prilocaine, d. Bupivacaine, e. Benzocaine, Cross-hypersensitivity has been found between lidocaine and which other dental local anesthetic?, a. Mepivacaine, b. Prilocaine, c. Bupivacaine, e. None of the above, Which percentage of local anesthetic in a dental cartridge has the longest duration of action?, a. 0.5%, b. 2%, c. 3%, d. 4%, The recommended concentration of epinephrine to combine with lidocaine is __ when hemostasis is needed., a. 1:20,000, b. 1:50,000, c. 1:100,000, d. 1:200,000, No justification exists for the use of epinephrine in a concentration greater than 1:200,000, except in cases in which hemostasis is needed., a. 1:200,000, b. 1:100,000, c. 1:50,000, d. 1:20,000, Dental local anesthetics containing vasoconstrictors should not be used in patients with cardiovascular disease. The vasoconstrictor will elevate the blood pressure too much., a. Both statements are true., b. Both statements are false., c. The first statement is true, the second statement is false., Which local anesthetic will have the shortest duration of action?, a. Lidocaine (plain) without vasoconstrictor, b. Lidocaine with vasoconstrictor, c. Mepivacaine with vasoconstrictor, d. Prilocaine with vasoconstrictor, Which of the following dental local anesthetics are available without vasoconstrictor? (Select all that apply.), a. Mepivacaine, b. Prilocaine, c. Articaine, d. Bupivacaine, The rate of local anesthetic absorption is increased by the presence of local inflammation, True , False , Benzocaine cannot be converted to a water-soluble form for injection., True, False , Patients who are allergic to procaine are not likely to display cross-hypersensitivity to lidocaine., True, False , For lengthy dental procedures, bupivacaine is recommended over lidocaine because bupivacaine has a longer duration of action., True , False , The recommended concentration of epinephrine to combine with a local anesthetic is 1:200,000 for most procedures., True , False , No justification exists for the use of epinephrine in a concentration greater than 1:200,000, except in cases in which hemostasis is needed., True , False , A patient can produce endogenous epinephrine far in excess of that administered in dentistry in the presence of inadequate anesthesia., True , False , Levonordefrin is more potent than epinephrine., True , False .

Chapter 10-Pharm

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