Mutation - A change in the DNA sequence, Point mutation - A single base pair change in the DNA sequence, Substitution mutation - A base is replaced by a different base in the DNA sequence, Frame Shift - The reading frame of the codons is shifted left or right, Insertion mutation - a base is inserted into the DNA sequence leading to frame shift, Deletion mutation - a base is removed from the DNA sequence leading to frame shift, Silent mutation - A type of substitution mutation that leads to no change in the primary protein sequence, Missense mutation - A type of substitution mutation that causes an amino acid to change but leave the others unaltered, Nonsense mutation - A type of substitution mutation that causes an early STOP codon, leading to a shorter polypeptide chain, Sickle Cell Anaemia - A substitution mutation disease that leads to misfolding of the beta-globin chain of haemoglobin, leading to the cell become sickle-shaped,

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