A "post integrity test" typically ____ Pre-Use, Post-Sterilization Integrity Testing (PUPSIT), especially in the ____ of pharmaceutical and biopharmaceutical manufacturing. PUPSIT is a ____ quality control ____ that ____ the integrity of a sterilizing-grade filter and its associated components after sterilization but before product filtration. This ____ that the filter, including its housing, connections, and support structures, has not been damaged during sterilization or ____, ____ potential contamination of the final product. PUPSIT (Pre-Use Post Sterilization Integrity Testing) is a European ____ requirement for sterile medicinal products. The ____ first came out in the 1996 version of Annex 1 (26 years ago), but PUPSIT came ____ when the European Medicines Agency (EMA) ____ the latest official version of Annex 1 in 2008. PUPSIT is a ____ work step in final ____ filtration (final filling) for biopharmaceutical manufacturers, except when ____ unfeasible.

AB PUPSIT

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