1) Which of the following is a non-selective COX inhibitor? a) A. Celecoxib  b) B. Acetaminophen c) C. Ibuprofen d) D. Nimesulide 2) What is the primary site of action for opioids? a) A. GABA receptors  b) B. NMDA receptors c) C. Mu-opioid receptors d) D. Histamine receptors 3) Which NSAID is associated with a lower risk of GI side effects? a) A. Aspirin  b) B. Indomethacin c) C. Celecoxib d) D. Naproxen 4) What is the main adverse effect of acetaminophen overdose? a) A. Nephrotoxicity  b) B. Hepatotoxicity c) C. Neurotoxicity d) D. Cardiotoxicity 5) Which opioid is commonly used for managing postoperative pain? a) A. Methadone  b) B. Tramadol c) C. Codeine d) D. Morphine 6) What is the mechanism of action of NSAIDs? a) A. Block dopamine receptors  b) B. Inhibit prostaglandin synthesis c) C. Activate opioid receptors d) D. Enhance serotonin levels 7) Which enzyme is primarily responsible for metabolism of codeine to morphine? a) A. CYP2D6  b) B. CYP3A4 c) C. CYP2C9 d) D. MAO-A 8) Which analgesic is considered safe during pregnancy? a) A. Aspirin  b) B. Ibuprofen c) C. Acetaminophen  d) D. Ketorolac 9) What is a unique side effect of morphine? a) A. Hypertension  b) B. Constipation c) C. Diarrhea d) D. Tinnitus 10) 10. Which drug is classified as a partial opioid agonist? a) A. Buprenorphine  b) B. Fentanyl c) C. Methadone d) D. Meperidine

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